Type 2 Diabetes and TZDs (Thiazolidinediones) Fritz 9.24.09
نویسندگان
چکیده
منابع مشابه
Type 2 diabetes, thiazolidinediones, and cardiovascular risk.
Type 2 diabetes is a common disorder with an increased risk of macrovascular complications. Achieving adequate glycaemic control is an important aim of therapy. Thiazolidinediones, or glitazones, have been used for the treatment of diabetes for a decade. Rosiglitazone and pioglitazone are currently available, however recent concerns around cardiovascular safety have led to restrictions on their...
متن کاملEffectiveness and side effects of thiazolidinediones for type 2 diabetes.
OBJECTIVE To assess effectiveness and side effects of thiazolidinediones (TZDs) as adjunctive therapy in suboptimally controlled patients with type 2 diabetes. DESIGN AND SETTING Review of a prospectively recorded database at the Royal Melbourne Hospital diabetes clinic. PARTICIPANTS 203 patients with type 2 diabetes who received pioglitazone or rosiglitazone between 1 May 2000 and 31 Octob...
متن کاملThiazolidinediones and blood lipids in type 2 diabetes.
We evaluated study population characteristics and treatment effects on blood lipids between studies in which either rosiglitazone (RSG) or pioglitazone (PIO) was investigated in patients with type 2 diabetes. We performed a summary analysis of all published double-blind, placebo-controlled studies with RSG (4 and 8 mg/d) and PIO (15, 30, and 45 mg/d). Data were analyzed by the random-effects mo...
متن کاملInflammatory Cytokines and type 2 diabetes
Inflammatory cytokines increase in patients with type 2 diabetes (T2D) and metabolic syndrome. This review focuses on inflammatory cytokines such as C-reactive protein (CRP), tumor necrosis factor (TNF-α), and adiponectin, a cytokine produced by adipose tissue and associated with insulin sensitivity. Despite the major role of cytokines in the development of T2D, in the case of adiponectin still...
متن کاملLack of association between thiazolidinediones and macular edema in type 2 diabetes: the ACCORD eye substudy.
OBJECTIVE To assess the cross-sectional association of thiazolidinediones with diabetic macular edema (DME). METHODS The cross-sectional association of DME and visual acuity with thiazolidinediones was examined by means of baseline fundus photographs and visual acuity measurements from the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. Visual acuity was assessed in 9690 par...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2009
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.94.11.9988